GHK is a tripeptide molecule with the sequence glycyl-histidyl-lysine. It is naturally present in human blood, saliva and urine. The concentration of GHK in the blood is 200ng/mL (10-7M) at the age of 20, and the concentration drops to 80ng/mL at the age of 60. This decline phenomenon is directly related to the significant decline in the ability of human organs to regenerate. In 1973, Pickart first isolated GHK-Cu, a tripeptide substance found in the study of active substances that act on both aging and young tissues.


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The sequence of the peptide is glycyl-L-histidyl-L-lysine, and it has a strong affinity for copper ions, forming a GHK-Cu complex. Research proves that GHK functions as a complex with copper ions



Clinical application of GHK-Cu

A large number of clinical research experiments have found that GHK-Cu can improve the skin quality of women around the age of 50. The production of collagen is used as the evaluation standard, and the method is immunohistochemistry of biopsy samples. The experimental process is as follows, when GHK-Cu cream is used on the thigh for one month, GHK-Cu has obvious effect of promoting collagen synthesis. GHK-Cu is effective in 70% of women, vitamin C is effective in 50% of women, and tretinoin is effective in 40% of women. 71 women with mildly or severely aging facial skin experienced significant improvement in skin aging after using GHK-Cu cream for 12 weeks. GHK-Cu improves skin laxity, clarity and appearance, reduces the depth of fine lines and wrinkles, and increases skin density and thickness.



After 12 weeks of GHK-Cu eye cream in 41 women with mildly or severely aging facial skin, GHK-Cu showed significant anti-wrinkle effects and increased skin density and thickness compared to a vitamin K-treated control group. In another set of experiments, 61 women between the ages of 50 and 59 who used GHK-Cu face cream twice a day had improved skin firmness, clarity, fine lines, roughness, hyperpigmentation, and skin density. and thickness increase.



Histochemical biopsy analysis showed that the cream stimulated skin keratinocyte proliferation. The results of these experiments can prove that GHK-Cu cream has the following effects:

(1) The skin is firm and elastic.

(2) Improve skin density and toughness.

(3) Reduce fine and deep lines.

(4) Increase the brightness.

(5) Reduce pigmentation and spots.

(6) Significantly increase keratinocyte proliferation.