Skin cell aging is the basis of skin diseases, so anti-aging is not only the fundamental problem of beauty, but also the key to skin care. The ability of basal cells to divide decreases with age, while apoptosis increases with age. According to the principle and process of wrinkle formation, the developed anti-aging and anti-wrinkle active ingredients mainly include: ingredients that affect the growth and metabolism of tissue cells, such as cell-K: factor, certain animal and plant extracts, fruit acids, sheep placenta, etc. ; Active ingredients that promote skin moisturizing and repair skin barrier function, such as ceramide, hyaluronic acid, sodium pyrrolidone carboxylate, etc.; ingredients that resist oxidative damage, such as superoxide dismutase, glutathione peroxidase, metal sulfur Protein MT, vitamin E and vitamin C, coenzyme QlO, etc.
In addition, two anti-UV ingredients are added to anti-aging and anti-wrinkle products to help the skin reduce skin damage caused by sun exposure. Promoting microvascular circulation and improving blood supply is a popular method for skin anti-aging in the world in recent years. Enhancing the metabolism of skin tissue and promoting the growth of Kemppi cells is an important strategy to delay skin aging and maintain a healthy complexion. Many biotech products developed in recent years have a unique role in this regard, such as alkaline phosphatase to promote skin regeneration, bFGF, EGF, AFGF, TGF, PDGF, IGF, TF, calf serum peptide, pineal gland Protein, albumin, etc. have such effects.
Sheep placenta is also an effective complex that can delay skin aging and contains a variety of bioactive peptides. It is an active embryonic cell essence extracted and extracted directly from the placenta of a 3-month-old ewe. Its active ingredients include 10 water-soluble vitamins, 16 amino acids, 10 minerals, and epidermal growth factor (EGF). . SOD and the active factor named vitamin X, mucopolysaccharide, lipoprotein, enzyme, hormone, lecithin and thymosin. Medical research has shown that these active substances can penetrate the deep tissue of the skin, stimulate the division and activation of human tissue cells, and promote the decomposition and discharge of aging cells, thereby delaying skin aging. Sheep placenta nutrient solution can prevent skin aging, smooth skin and enhance its elasticity, which is an important research topic in modern skin care products.
Superoxide dismutase (SOD) is a metalloenzyme containing copper, zinc, manganese and iron, widely present in various tissues of organisms, and is the only antioxidant enzyme that can specifically remove superoxide anion. SOD can be extracted from red blood cells of cattle and pigs, as well as from spinach, cabbage, prickly pear, yeast and bacteria. At present, it is known that there are at least five SODs such as Cu-SOD, Mn-SOD, Fe-SOD, Zn-SOD and EC-SOD. The use of SOD as an active enzyme as a cosmetic ingredient is affected by many factors, such as short half-life, short residence time in the body, usually only 6-20min, molecular weight around 32000, not easy to penetrate the stratum corneum and cell membrane and has antigenicity, etc. . In order to solve these unfavorable factors, at present, molecular engineering methods are mainly used in China to molecularly modify its inactive groups with water-soluble macromolecules such as heparin group polyethylene glycol # dextran or use liposomes that can increase its transdermal absorption. and other new carriers for embedding.
Metallothionein (MT) refers to a class of low molecular weight, high sulfhydryl content (20% to 30%) proteins with unique properties or active peptides that can bind a large amount of metal ions. It exists widely in the human body, animals, plants and microorganisms, and its physical and chemical properties are basically the same. . The MT molecule is oval in shape, with a molecular weight of 6500 Daltons and a diameter of 30-50A. It is divided into two domains. Each molecule contains 7-12 metal atoms. It has special light absorption. Heat resistance. MT has a very conserved primary structure and similar spatial structure, and MT exists in multiple subtypes in many species. There are four MT subtypes in mammals, namely MT-I, MT-II, MT-III, MT-IV; these subtypes are divided into different isomers, such as MT-IA. MT-IB, etc., although the isomers are not completely identical in nature and function, they are highly homologous in sequence. MT is one of the most important, bizarre, and physiologically functional active substances in animals. Because the MT molecule contains 20 free sulfhydryl (-SH) genes, as well as multiple sulfhydryl clusters composed of them, it is used in biology.
The body has a wide range of biological functions. Studies have shown that MT has a significant effect in resisting ionizing radiation, ultraviolet radiation, removing metal toxins, treating peptic ulcer, myocardial infarction, various inflammations, cancer, beauty and skin care, reducing the harm of smoking and environmental pollution to the human body, and anti-allergic. .